tert-butyl 4-(2-formyl-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-formyl-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate
• CAS No.: 1017782-93-2
• Molecular Formula: C₁₆H₂₁N₃O₅
• Molecular Weight: 335.36
• Mol file: 1017782-93-2.mol

Synonyms:4-(2-formyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester

Chemical Property of tert-butyl 4-(2-formyl-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate

Chemical Property:

• Melting Point: 145-147°

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(2-Formyl-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate ^*data from reagent suppliers

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Technology Process of tert-butyl 4-(2-formyl-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate

There total 2 articles about tert-butyl 4-(2-formyl-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-nitrobenzaldehyde (6361-21-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(2-formyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester (1017782-93-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 4h;

DOI:10.1021/jm200326p

Reference yield: 99.0%

2-fluoro-5-nitrobenzaldehye (27996-87-8) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(2-formyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester (1017782-93-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

Reference yield: 100.0%

4-(2-formyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester (1017782-93-2) → 4-(2-(hydroxymethyl)-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester (955369-05-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm200326p

upstream raw materials:

2-fluoro-5-nitrobenzaldehye

1-t-Butoxycarbonylpiperazine

2-chloro-5-nitrobenzaldehyde

Downstream raw materials:

4-(2-(hydroxymethyl)-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester

4-(2-allyloxymethyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester

4-(2-allyloxymethyl-4-aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

4-{2-allyloxymethyl-4-[4-(3-allyloxymethylphenyl)-pyrimidin-2-ylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

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