4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

Base Information

Chemical Name:4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol
CAS No.:693790-49-7
Molecular Formula:C₃₉H₅₇NO₅SSi₂
Molecular Weight:708.122
Hs Code.:

4-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

Synonyms:4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

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Chemical Property of 4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

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Technology Process of 4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

There total 9 articles about 4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 693790-08-8
(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)thiobutyramide

: 308240-79-1
(S)-1-bromo-4-(tert-butyldimethylsilanyloxy)-3-methylbutan-2-one

: 693790-49-7
4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 14h;
DOI:10.1139/v03-199

Reference yield:

: 693790-33-9
(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid

: 693790-49-7
4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl chloroformate; Et₃N / tetrahydrofuran / 0 - 20 °C

1.2: 93 percent / aq. NH₄OH / tetrahydrofuran / 0 - 20 °C

2.1: 99 percent / Lawesson's reagent / diisopropyl ether / 0.5 h / 20 °C

3.1: 73 percent / 2,6-lutidine / CH₂Cl₂ / 14 h / 20 °C

With Lawessons reagent; 2,6-dimethylpyridine; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane; di-isopropyl ether;
DOI:10.1139/v03-199

Reference yield:

: 693790-06-6
(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyramide

: 693790-49-7
4-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-[3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl]-4,5-dihydro-thiazol-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Lawesson's reagent / diisopropyl ether / 0.5 h / 20 °C

2: 73 percent / 2,6-lutidine / CH₂Cl₂ / 14 h / 20 °C

With Lawessons reagent; 2,6-dimethylpyridine; In dichloromethane; di-isopropyl ether;
DOI:10.1139/v03-199