N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Base Information

Chemical Name:N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide
CAS No.:1240517-78-5
Molecular Formula:C₂₃H₂₃ClN₄O₄S₂
Molecular Weight:519.045
Hs Code.:

Synonyms:N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

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Chemical Property of N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

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Technology Process of N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

There total 13 articles about N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1240518-66-4
N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

: 1240517-78-5
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 - 25 ℃; Inert atmosphere;

Reference yield:

: 65610-13-1
3-fluoro-1,2-benzenedicarbonitrile

: 1240517-78-5
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrazine hydrate / ethanol / 70 °C / Inert atmosphere

2.1: triethylamine; dmap / dichloromethane; acetonitrile / 0.5 h / Inert atmosphere

3.1: dichloromethane / 62 h / 45 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1.17 h

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

6.1: sodium hydroxide / methanol; tetrahydrofuran / 1 h / 45 °C

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

8.1: triethylamine / dichloromethane / 0.5 h

8.2: 0.5 h / 20 °C

9.1: diethyl ether; tetrahydrofuran / 2 h / 20 °C

10.1: sodium tetrahydroborate / methanol / 2 h / 20 - 25 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetonitrile; 5.1: |Mitsunobu Displacement;
DOI:10.1021/jm301572h

Reference yield:

: 1240518-54-0
3-amino-1H-indazole-4-carbonitrile

: 1240517-78-5
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

2.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h

4.2: 0.5 h / 20 °C

5.1: diethyl ether; tetrahydrofuran / 2 h / 20 °C

6.1: sodium tetrahydroborate / methanol / 2 h / 20 - 25 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm301572h