N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Base Information

Chemical Name:N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide
CAS No.:1240518-66-4
Molecular Formula:C₂₃H₂₁ClN₄O₄S₂
Molecular Weight:517.029
Hs Code.:

Synonyms:N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Chemical Property of N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Technology Process of N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

There total 12 articles about N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1240518-65-3
N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

: 75-16-1
methylmagnesium bromide

: 1240518-66-4
N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;
DOI:10.1021/jm301572h

Reference yield:

: 65610-13-1
3-fluoro-1,2-benzenedicarbonitrile

: 1240518-66-4
N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / ethanol / 70 °C / Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

3.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.5 h

5.2: 0.5 h / 20 °C

6.1: diethyl ether; tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrazine hydrate; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm301572h

Reference yield:

: 1240518-54-0
3-amino-1H-indazole-4-carbonitrile

: 1240518-66-4
N-({3-[(4-acetyl-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

2.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h

4.2: 0.5 h / 20 °C

5.1: diethyl ether; tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm301572h