methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate

Base Information

Chemical Name:methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate
CAS No.:430472-54-1
Molecular Formula:C₃₉H₃₅BrN₂O₃
Molecular Weight:659.622
Hs Code.:

Synonyms:methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate

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Technology Process of methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate

There total 9 articles about methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 337521-16-1
methyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-1-methyl-2-naphthoate

: 430472-54-1
methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 21h; Reflux;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 337521-16-1
methyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-1-methyl-2-naphthoate

: 34241-39-9
azobisisobutyronitrile

: 430472-54-1
methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate

Guidance literature:: With N-Bromosuccinimide; In tetrachloromethane;

Reference yield:

: 247174-15-8
6-bromo-2-tert-butyldimethylsilyloxy-1-methylnaphthalene

: 430472-54-1
methyl-1-(bromomethyl)-6-[1-hydroxy-2-methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)propyl]-2-naphthoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

1.2: 0.83 h / -70 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: pyridine / 1 h / 0 °C

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 21 h / Reflux

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; palladium diacetate; triethylamine; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017