1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride

Base Information

• Chemical Name: 1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride
• CAS No.: 84175-38-2
• Molecular Formula: C₁₅H₁₈ClNO₂*ClH
• Molecular Weight: 316.227
• Mol file: 84175-38-2.mol

Synonyms:1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride

Chemical Property of 1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride

There total 4 articles about 1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + (3E)-4-(4-chlorophenyl)-3-buten-2-one (30626-03-0) → 1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride (84175-38-2)

Guidance literature:

With hydrogenchloride; In ethanol; at 80 ℃; for 4h;

DOI:10.1021/jm00357a020

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride (84175-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / aq. NaOH / 1 h

2: 29 percent / conc. HCl / ethanol / 4 h / 80 °C

With hydrogenchloride; sodium hydroxide; In ethanol;

DOI:10.1021/jm00357a020

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (3E)-4-(4-chlorophenyl)-3-buten-2-one (30626-03-0) + morpholin hydrochloride (10024-89-2) → 1t-(4-chloro-phenyl)-5-morpholino-pent-1-en-3-one; hydrochloride (84175-38-2)

Guidance literature:

With benzene;

DOI:10.1021/jo01158a007

upstream raw materials:

formaldehyd

(3E)-4-(4-chlorophenyl)-3-buten-2-one

morpholin hydrochloride

morpholine