2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide

Base Information

Chemical Name:2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide
CAS No.:1201933-99-4
Molecular Formula:C₂₃H₂₈ClN₇O₂
Molecular Weight:469.974
Hs Code.:

Synonyms:2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide

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Chemical Property of 2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide

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Technology Process of 2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide

There total 5 articles about 2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1201935-36-5
1-methyl-4-(4-amino-1H-pyrazol-1-yl)piperidine

: 1201935-46-7
2-[(2,5-dichloropyridin-4-yl)amino]-N-methoxy-N-methylbenzamide

: 1201933-99-4
2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 150 ℃; for 3h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 106-52-5
N-methyl-4-hydroxypiperidine

: 1201933-99-4
2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 25 °C

2: hydrogen / palladium on activated charcoal / ethanol / 16 h / 25 °C / 760.05 Torr / Inert atmosphere

3: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 3 h / 150 °C / Inert atmosphere; Microwave irradiation

With di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; triphenylphosphine; palladium on activated charcoal; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide;

Reference yield:

: 1201935-35-4
1-methyl-4-(4-nitro-1H-pyrazol-1-yl)piperidine

: 1201933-99-4
2-((5-chloro-2-((1-(1-methyl-4-piperidyl)pyrazol-4-yl)amino)-4-pyridyl)amino)-N-methoxy-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / ethanol / 16 h / 25 °C / 760.05 Torr / Inert atmosphere

2: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 3 h / 150 °C / Inert atmosphere; Microwave irradiation

With hydrogen; caesium carbonate; palladium on activated charcoal; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; N,N-dimethyl acetamide;