(S)-N-diphenylphosphinoglutamic acid diethyl ester

Base Information

• Chemical Name: (S)-N-diphenylphosphinoglutamic acid diethyl ester
• CAS No.: 368879-75-8
• Molecular Formula: C₂₁H₂₆NO₄P
• Molecular Weight: 387.415
• Mol file: 368879-75-8.mol

Synonyms:(S)-N-diphenylphosphinoglutamic acid diethyl ester

Chemical Property of (S)-N-diphenylphosphinoglutamic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-N-diphenylphosphinoglutamic acid diethyl ester

There total 1 articles about (S)-N-diphenylphosphinoglutamic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diethyl-L-glutamate hydrochloride (1118-89-4) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (S)-N-diphenylphosphinoglutamic acid diethyl ester (368879-75-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 5 ℃; for 3h;

DOI:10.1039/b009074n

Reference yield: 88.0%

di-μ-chloro-bis(1,5-cyclooctadiene)dirhodium (12092-47-6) + (S)-N-diphenylphosphinoglutamic acid diethyl ester (368879-75-8) → [(cycloocta-1,5-diene)RhCl((S)-N-diphenylphosphinoglutamic acid diethyl ester-P)]

Guidance literature:

In dichloromethane; to soln. (RhCl(cod))2 in CH2Cl2 soln. ligand in CH2Cl2 was added dropwise and stirred for 30 min; soln. was concd., chromy. on silica (Et2O); elem. anal.;

DOI:10.1039/b009074n

Reference yield: 80.0%

dichloro(1,5-cyclooctadiene)platinum(ll) (12080-32-9) + (S)-N-diphenylphosphinoglutamic acid diethyl ester (368879-75-8) → cis-[PtCl2((S)-N-diphenylphosphinoglutamic acid diethyl ester-P)2]

Guidance literature:

In dichloromethane; to soln. (PtCl2(cod)) in CH2Cl2 ligand was added and stirred for 20 min; soln. was concd., residue was washed with Et2O, solvent was evapd. to dryness; elem. anal.;

DOI:10.1039/b009074n

upstream raw materials:

diethyl-L-glutamate hydrochloride

chloro-diphenylphosphine