ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate

Base Information

• Chemical Name: ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate
• CAS No.: 18343-02-7
• Molecular Formula: C12H15NO5
• Molecular Weight: 253.25100
• Hs Code.: 2933399090
• Mol file: 18343-02-7.mol

Synonyms:ethyl 3-ethoxycarbonylmethoxy-isonicotinate;Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate;Ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate;4-Carbethoxy-pyridoxy-(3)-essigsaeureethylester;

Chemical Property of ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate

Chemical Property:

• Boiling Point: 359.6±27.0 °C(Predicted)
• PKA: 2.53±0.10(Predicted)
• PSA: 74.72000
• Density: 1.183±0.06 g/cm3(Predicted)
• LogP: 1.20020
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate

There total 5 articles about ethyl 3-(2-ethoxy-2-oxoethoxy)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 2-hydroxyacetate (623-50-7) + ethyl 3-hydroxyisonicotinate (18342-97-7) → Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate (18343-02-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 5 - 20 ℃; for 1h;

Reference yield: 62.0%

ethyl 3-hydroxyisonicotinate (18342-97-7) + ethyl bromoacetate (105-36-2) → Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate (18343-02-7)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

Reference yield: 61.0%

ethyl 3-hydroxyisonicotinate (18342-97-7) + ethyl acetate (141-78-6) → Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate (18343-02-7)

Guidance literature:

ethyl 3-hydroxyisonicotinate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -10 - 20 ℃; for 16h;

ethyl acetate; With hydrogenchloride; In water;

upstream raw materials:

ethyl 3-hydroxyisonicotinate

ethyl bromoacetate

ethyl 2-hydroxyacetate

3-hydroxyisonicotinic acid

Downstream raw materials:

furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

ethyl 3-(((trifluoromethyl) sulfonyl)oxy)furo[2,3-c]pyridine-2-carboxylate

Ethyl furo<2,3-c>pyridine-2-carboxylate