(S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

Base Information

Chemical Name:(S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide
CAS No.:1359938-52-5
Molecular Formula:C₁₆H₁₇Cl₃N₂O
Molecular Weight:359.683
Hs Code.:

Synonyms:(S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

Suppliers and Price of (S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

There total 4 articles about (S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24123-89-5
(Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one

: (R)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

: 1359938-52-5
(S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

: C₁₆H₁₇Cl₃N₂O

Guidance literature:: Multi-step reaction with 2 steps

1.1: [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; water; sodium formate / isopropyl alcohol / 5 h / 67 °C

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 0 °C / Alkaline conditions

2.2: 6 h / 115 °C

With [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; water; sodium formate; In 5,5-dimethyl-1,3-cyclohexadiene; isopropyl alcohol; 2.1: Overman rearrangement;
DOI:10.1021/op200378r

Reference yield:

: 1193-65-3
3-quinuclidinone hydrochloride

: (R)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

: 1359938-52-5
(S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

: C₁₆H₁₇Cl₃N₂O

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 25 - 30 °C

1.2: 30 - 50 °C

2.1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / toluene / -20 - -10 °C

3.1: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 0 °C / Alkaline conditions

3.2: 6 h / 115 °C

With dimethylsulfide borane complex; sodium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; toluene; 3.1: Overman rearrangement;
DOI:10.1021/op200378r

Reference yield:

: 100-52-7
benzaldehyde

: (R)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

: 1359938-52-5
(S)-N-[(1-azabicyclo[2.2.2]oct-2-en-2-yl)phenyl-methyl]-2,2,2-trichloroacetamide

: C₁₆H₁₇Cl₃N₂O

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 25 - 30 °C

1.2: 30 - 50 °C

2.1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / toluene / -20 - -10 °C

3.1: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 0 °C / Alkaline conditions

3.2: 6 h / 115 °C

With dimethylsulfide borane complex; sodium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; toluene; 3.1: Overman rearrangement;
DOI:10.1021/op200378r