3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 229015-76-3
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.266
• Hs Code.: 2933199090
• Mol file: 229015-76-3.mol

Synonyms:3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Melting Point: 130-132 °C
• Boiling Point: 458.3±40.0 °C(Predicted)
• PKA: 10?+-.0.10(Predicted)
• PSA: 64.21000
• Density: 1.203±0.06 g/cm3(Predicted)
• LogP: 2.26200

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

There total 11 articles about 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-hydroxy-4-oxo-4-(4-methoxyphenyl)but-2-enoic acid ethyl ester (63913-14-4) → ethyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (938182-54-8,229015-76-3)

Guidance literature:

With semicarbazide hydrochloride; In water; for 2h; Reflux; Green chemistry;

DOI:10.1039/c4gc02028f

Reference yield: 96.0%

ethyl 3-(4-methoxybenzoyl)pyruvate (35322-20-4) → ethyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (938182-54-8,229015-76-3)

Guidance literature:

With hydrazine; In ethanol; at 60 ℃; for 4h;

Reference yield: 84.0%

oxalic acid diethyl ester (95-92-1) + 1-(4-methoxyphenyl)ethanone (100-06-1) → ethyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (938182-54-8,229015-76-3)

Guidance literature:

1-(4-methoxyphenyl)ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

oxalic acid diethyl ester; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrazine hydrate; acetic acid; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.03.072

upstream raw materials:

ethyl 3-(4-methoxybenzoyl)pyruvate

4-methoxyacetophenone-ethoxycarbonylhydrazone

oxalic acid diethyl ester

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid

C₁₄H₁₇N₃O₃

C₁₅H₁₉N₃O₄

C₁₄H₁₇N₃O₃