4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER
• CAS No.: 35322-20-4
• Molecular Formula: C13H14O5
• Molecular Weight: 250.251
• Hs Code.: 2918990090
• Mol file: 35322-20-4.mol

Synonyms:

Chemical Property of 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 7.79E-07mmHg at 25°C
• Melting Point: 52-57 °C
• Boiling Point: 407°Cat760mmHg
• Flash Point: 182°C
• PSA: 69.67000
• Density: 1.182g/cm³
• LogP: 1.40020

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-(4-methoxyphenyl)-2,4-dioxobutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

There total 6 articles about 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

oxalic acid diethyl ester (95-92-1) + 1-(4-methoxyphenyl)ethanone (100-06-1) → ethyl 3-(4-methoxybenzoyl)pyruvate (35322-20-4)

Guidance literature:

1-(4-methoxyphenyl)ethanone; With sodium; In ethanol; at 20 ℃; for 0.5h;

oxalic acid diethyl ester; at 20 - 80 ℃; for 3h;

Reference yield: 57.0%

→ ethyl 3-(4-methoxybenzoyl)pyruvate (35322-20-4)

Guidance literature:

With sodium; In ethanol; for 2.5h; Reflux;

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → ethyl 3-(4-methoxybenzoyl)pyruvate (35322-20-4)

Guidance literature:

at 20 ℃; Cooling with ice;

DOI:10.1016/j.tet.2015.02.030

upstream raw materials:

oxalic acid diethyl ester

1-(4-methoxyphenyl)ethanone

ethanol

4-methoxy-benzaldehyde

Downstream raw materials:

6-[2-(4-Methoxy-phenyl)-2-oxo-ethyl]-2-methyl-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one

3-Mercapto-6-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-2H-[1,2,4]triazin-5-one

1-(4-Fluoro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

(Z)-3-(2-(4-methoxyphenyl)-2-oxoethylidene)-3,4-dihydroquinoxalin-2(1H)-one

Refernces

• 1、 Rossi,Schinz. "-". . p. 1967,1972. Retrieved 1949.
• 2、 Uygun, Meltem Tan,Amudi, Karina,Tura?l?, ?rem Do?an,Menges, Nurettin. "A new synthetic approach for pyrazolo[1,5-a]pyrazine-4(5H)-one derivatives and their antiproliferative effects on lung adenocarcinoma cell line". . . Retrieved 2021/01/11.
• 3、 Akbarzadeh, Tahmineh,Eslami, Azadeh,Faramarzi, Mohammad Ali,Mahdavi, Mohammad,Mirfazli, Seyedeh Sara,Saeedi, Mina,Zardkanlou, Mahsa. "Design and synthesis of novel 5-arylisoxazole-1,3,4-thiadiazole hybrids as α-glucosidase inhibitors". . p. 436 - 444. Retrieved 2021/10/04.