(1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:(1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester
CAS No.:78176-52-0
Molecular Formula:C₂₂H₂₈O₇
Molecular Weight:404.46
Hs Code.:

Synonyms:(1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester

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Chemical Property of (1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester

Chemical Property:

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Technology Process of (1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester

There total 6 articles about (1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78176-50-8
(1S,2R,4R)-4-Hydroxy-2-(5-methoxy-1-methoxymethoxy-naphthalene-2-carbonyl)-cyclohexanecarboxylic acid methyl ester

: 78176-51-9
(3aR,5R,7aS)-5-Hydroxy-3-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-hexahydro-isobenzofuran-1-one

: 78176-52-0
(1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid; at 25 ℃; for 4h; under 2585.7 Torr; Title compound not separated from byproducts;
DOI:10.1016/0040-4039(81)80003-2

Reference yield:

: 3588-80-5
5-methoxynaphthalen-1-ol

: 78176-52-0
(1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / NaH / dimethylformamide

2: 1)t-butyllithium / 1) DME, -25 deg C 2) -25 deg C

3: hydrogen / 5percent Pd/C / acetic acid; methanol / 4 h / 25 °C / 2585.7 Torr

With hydrogen; tert.-butyl lithium; sodium hydride; palladium on activated charcoal; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(81)80003-2

Reference yield:

: 93603-11-3
1-methyl hydrogen 1,2-cis-1,2-cyclohex-4-ene dicarboxylate

: 78176-52-0
(1S,2R,4R)-4-Hydroxy-2-[hydroxy-(5-methoxy-1-methoxymethoxy-naphthalen-2-yl)-methyl]-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / I₂, KI; NaHCO₃

2: 97 percent / tri-n-butyltin hydride

3: 1)t-butyllithium / 1) DME, -25 deg C 2) -25 deg C

4: hydrogen / 5percent Pd/C / acetic acid; methanol / 4 h / 25 °C / 2585.7 Torr

With hydrogen; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hydrogencarbonate; potassium iodide; palladium on activated charcoal; In methanol; acetic acid;
DOI:10.1016/0040-4039(81)80003-2