5-Methoxynaphthalen-1-ol

Base Information

• Chemical Name: 5-Methoxynaphthalen-1-ol
• CAS No.: 3588-80-5
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Hs Code.: 2909500000
• DSSTox Substance ID: DTXSID70453781
• Nikkaji Number: J760.807A
• Wikidata: Q82275016
• Mol file: 3588-80-5.mol

Synonyms:5-methoxynaphthalen-1-ol;3588-80-5;5-Methoxy-1-naphthol;5-METHOXY-1-NAPHTHALENOL;1-Hydroxy-5-methoxynaphthalene;1-Methoxy-5-naphthol;SCHEMBL3171781;DTXSID70453781;WLZPYTDCBHITRF-UHFFFAOYSA-N;AB7392;MFCD00512042;AKOS003239093;AS-44841;CS-0308299;FT-0671282;EN300-1143461

Chemical Property of 5-Methoxynaphthalen-1-ol

Chemical Property:

• Melting Point: 130-135°C
• PSA: 29.46000
• LogP: 2.55400
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.068079557
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-1-naphthalenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC2=C1C=CC=C2O
• Uses: 5-Methoxy-1-naphthalenol (cas# 3588-80-5) is a compound useful in organic synthesis.

Technology Process of 5-Methoxynaphthalen-1-ol

There total 6 articles about 5-Methoxynaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C11H10O2 → 5-methoxynaphthalen-1-ol (3588-80-5) + 8-methoxy-naphthalen-1-ol (3588-75-8)

Guidance literature:

With dichlorotricarbonylruthenium(II) dimer; In 1,2-dichloro-ethane; at 60 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo901504n

Reference yield: 62.0%

methanol (67-56-1) + 1,5-dihydroxynaphthalene (83-56-7) → 5-methoxynaphthalen-1-ol (3588-80-5) + 1,5-dimethoxynaphthalene (10075-63-5)

Guidance literature:

With hydrogenchloride; for 240h; Ambient temperature;

DOI:10.1071/CH9930731

Reference yield: 44.0%

1,5-dimethoxynaphthalene (10075-63-5) → 5-methoxynaphthalen-1-ol (3588-80-5) + 1,5-dihydroxynaphthalene (83-56-7)

Guidance literature:

With Cyclohexyl iodide; In N,N-dimethyl-formamide; for 2.5h; Heating;

DOI:10.1016/j.tetlet.2008.04.070

upstream raw materials:

1,5-dihydroxynaphthalene

dimethyl sulfate

methanol

1-benzoyloxy-5-methoxy naphthalene

Downstream raw materials:

2-(8-hydroxy-4-methoxy-[1]naphthoyl)-benzoic acid

5-methoxynaphthoquinone

1-Hydroxy-5-methoxynaphthalin-2-carbonsaeure

1,5-dimethoxynaphthalene