2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole

Base Information

• Chemical Name: 2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole
• CAS No.: 81280-95-7
• Molecular Formula: C₃₂H₃₅NO₅
• Molecular Weight: 513.634
• Mol file: 81280-95-7.mol

Synonyms:2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole

Chemical Property of 2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole

There total 7 articles about 2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-<3',5'-dimethoxy-2'-(1',7'-dioxo-octyl)benzyl>-4,5-diphenyloxazole (81280-94-6) → 2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole (81280-95-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)93281-8

Reference yield:

(3,5-dimethoxyphenyl)acetic acid (4670-10-4) → 2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole (81280-95-7)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N'-dicyclohexylcarbodiimide, 4-dimethylaminopyridine / diethyl ether / 5.5 h / Ambient temperature

2: 83 percent / NH₄OAc / acetic acid / 1.5 h / Heating

3: 50 percent / AlCl₃ / CS₂ / 48 h / 0 - 20 °C

4: 94 percent / NaBH₄ / ethanol / 0.5 h / Ambient temperature

With dmap; sodium tetrahydroborate; aluminium trichloride; ammonium acetate; dicyclohexyl-carbodiimide; In carbon disulfide; diethyl ether; ethanol; acetic acid;

DOI:10.1016/S0040-4020(01)93281-8

Reference yield:

2-(3,5-dimethyloxyphenylmethyl)-4,5-diphenyloxazole (81280-92-4) → 2-(3,5-dimethoxy-2-(7'-hydroxy-1'-oxooctyl)-phenylmethyl)-4,5-diphenyloxazole (81280-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / AlCl₃ / CS₂ / 48 h / 0 - 20 °C

2: 94 percent / NaBH₄ / ethanol / 0.5 h / Ambient temperature

With sodium tetrahydroborate; aluminium trichloride; In carbon disulfide; ethanol;

DOI:10.1016/S0040-4020(01)93281-8

upstream raw materials:

2-<3',5'-dimethoxy-2'-(1',7'-dioxo-octyl)benzyl>-4,5-diphenyloxazole

7-oxo-octanoyl chloride

(3,5-dimethoxyphenyl)acetone

(3,5-dimethoxyphenyl)acetic acid

Downstream raw materials:

N-Benzoyl-N-{2-[2-(7-hydroxy-octanoyl)-3,5-dimethoxy-phenyl]-acetyl}-benzamide