Technology Process of 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate
There total 10 articles about 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1.5 h / 110 °C / Inert atmosphere
2: sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C
3: triethylsilane / dichloromethane / 1 h / 0 °C
4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane / 16 h / 80 °C
With
triethylsilane; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.8b01147
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere
1.2: 14 h / 105 °C
2.1: potassium acetate; XPhos / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 14 h / 105 °C / Reflux; Inert atmosphere
With
potassium acetate; caesium carbonate; N,N`-dimethylethylenediamine; XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid; triethylsilane / acetonitrile / 1.5 h / 130 °C / Microwave irradiation
2.1: lithium hydroxide; methanol / tetrahydrofuran / 2.5 h / 110 °C / Microwave irradiation
2.2: pH 7
3.1: caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere
3.2: 14 h / 105 °C
4.1: potassium acetate; XPhos / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 14 h / 105 °C / Reflux; Inert atmosphere
With
methanol; triethylsilane; potassium acetate; caesium carbonate; trifluoroacetic acid; lithium hydroxide; N,N`-dimethylethylenediamine; XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; 1,4-dioxane; acetonitrile;
