2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

Base Information

Chemical Name:2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate
CAS No.:1361941-28-7
Molecular Formula:C₂₇H₂₇N₃O₆
Molecular Weight:489.528
Hs Code.:

Synonyms:2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

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Chemical Property of 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

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Technology Process of 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

There total 9 articles about 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1361386-56-2
2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

: 1361941-27-6
1-methyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

: 1361941-28-7
2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

Guidance literature:: 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate; 1-methyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one; With sodium carbonate; In 1,4-dioxane; water; for 0.25h; Inert atmosphere;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 5h;

Reference yield:

: 93701-32-7
2,6-dibromobenzyl bromide

: 1361941-28-7
2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; N,N-dimethylethylenediamine / 1,4-dioxane / 0.5 h / Inert atmosphere; Reflux

2.2: 14 h / 105 °C

3.1: potassium acetate / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere

3.2: 14 h / 105 °C

4.1: sodium carbonate / 1,4-dioxane; water / 0.25 h / Inert atmosphere

4.2: 5 h / 100 °C

With potassium acetate; sodium carbonate; caesium carbonate; N,N-dimethylethylenediamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1361386-52-8
4-(tert-butyl)-N,N-diethyl-2-formylbenzamide

: 1361941-28-7
2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(1-methyl-5-nitro-6-oxo-1,6-dihydropyridin-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid; triethylsilane / acetonitrile / 1.5 h / 130 °C / Microwave irraradiation

2.1: lithium hydroxide / tetrahydrofuran; methanol / 2.5 h / 110 °C / Microwave irradiation

2.2: pH 7

3.1: caesium carbonate; N,N-dimethylethylenediamine / 1,4-dioxane / 0.5 h / Inert atmosphere; Reflux

3.2: 14 h / 105 °C

4.1: potassium acetate / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere

4.2: 14 h / 105 °C

5.1: sodium carbonate / 1,4-dioxane; water / 0.25 h / Inert atmosphere

5.2: 5 h / 100 °C

With triethylsilane; potassium acetate; sodium carbonate; caesium carbonate; N,N-dimethylethylenediamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;