2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide

Base Information

Chemical Name:2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide
CAS No.:1449004-35-6
Molecular Formula:C₂₈H₂₈BrClN₄O₇S₂
Molecular Weight:712.042
Hs Code.:

Synonyms:2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide

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Chemical Property of 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide

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Technology Process of 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide

There total 8 articles about 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1449004-35-6
2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

3: acetone / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; acetone;
DOI:10.1039/c3ob40236c

Reference yield:

: 110630-87-0
C₈H₅BrCl₂O₂

: 1449004-35-6
2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / acetone

2: acetone / 20 °C

With thionyl chloride; In acetone;
DOI:10.1039/c3ob40236c

Reference yield:

: 588679-10-1
ethyl 2-(4-bromo-2-chlorophenoxy)acetate

: 1449004-35-6
2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(N-tert-butoxycarbonyl-L-(2-phenyl)glycyl)sulfamoyl)phenylcarbamothioyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; 1,4-dioxane

2: thionyl chloride / N,N-dimethyl-formamide / Reflux

3: thionyl chloride / acetone

4: acetone / 20 °C

With thionyl chloride; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1039/c3ob40236c