2-Propen-1-amine,N-methyl-3-(3-pyridinyl)-,(2E)-(9CI)

Base Information

• Chemical Name: 2-Propen-1-amine,N-methyl-3-(3-pyridinyl)-,(2E)-(9CI)
• CAS No.: 228271-74-7
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.208
• Mol file: 228271-74-7.mol

Synonyms:2-Propen-1-amine,N-methyl-3-(3-pyridinyl)-,(2E)-(9CI)

Chemical Property of 2-Propen-1-amine,N-methyl-3-(3-pyridinyl)-,(2E)-(9CI)

Chemical Property:

• Boiling Point: 269.8±28.0 °C(Predicted)
• PKA: 8.97±0.10(Predicted)
• PSA: 24.92000
• Density: 0.994±0.06 g/cm3(Predicted)
• LogP: 1.70510

Purity/Quality:

99%min ^*data from raw suppliers

(E)-N-Methyl-3-(pyridin-3-yl)prop-2-en-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propen-1-amine,N-methyl-3-(3-pyridinyl)-,(2E)-(9CI)

There total 4 articles about 2-Propen-1-amine,N-methyl-3-(3-pyridinyl)-,(2E)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

methylamine (74-89-5) + (Z)-1-chloro-3-(3-pyridyl)-2-propene hydrochloride → (Z)-N-methyl-3-(3-pyridyl)-2-propenylamine (228271-74-7,228271-84-9)

Guidance literature:

In water; at 70 ℃; for 1h;

DOI:10.1016/S0223-5234(99)80051-8

Reference yield:

1-(pyridin-3-yl)-1-propyn-3-ol (61266-33-9) → (Z)-N-methyl-3-(3-pyridyl)-2-propenylamine (228271-74-7,228271-84-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 370 mg / quinoline, H₂ / Lindlar's catalyst / methanol / 18 h / 760 Torr

2: SOCl₂ / CHCl₃ / 3 h / Ambient temperature

3: 39 percent / H₂O / 1 h / 70 °C

With quinoline; thionyl chloride; hydrogen; Lindlar's catalyst; In methanol; chloroform; water;

DOI:10.1016/S0223-5234(99)80051-8

Reference yield:

3-(3'-pyridinyl)-(Z)-propenoic acid methyl ester (228271-59-8) → (Z)-N-methyl-3-(3-pyridyl)-2-propenylamine (228271-74-7,228271-84-9)

Guidance literature:

Multi-step reaction with 3 steps

1: DIBAL / toluene; hexane / 6.5 h / 0 °C

2: SOCl₂ / CHCl₃ / 3 h / Ambient temperature

3: 39 percent / H₂O / 1 h / 70 °C

With thionyl chloride; diisobutylaluminium hydride; In hexane; chloroform; water; toluene;

DOI:10.1016/S0223-5234(99)80051-8

upstream raw materials:

methylamine

1-(pyridin-3-yl)-1-propyn-3-ol

3-(3'-pyridinyl)-(Z)-propenoic acid methyl ester

(Z)-3-(3-pyridyl)-2-propen-1-ol

Refernces