9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N⁶-benzoyladenine

Base Information

• Chemical Name: 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N⁶-benzoyladenine
• CAS No.: 109303-87-9
• Molecular Formula: C₂₆H₂₂FN₅O₆
• Molecular Weight: 519.489
• Mol file: 109303-87-9.mol

Synonyms:9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N⁶-benzoyladenine

Chemical Property of 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N⁶-benzoyladenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N⁶-benzoyladenine

There total 1 articles about 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N⁶-benzoyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide (56632-81-6) + N-benzoyladenine (4005-49-6) → 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N6-benzoyladenine (109303-87-9)

Guidance literature:

With molecular sieve; In dichloromethane; for 72h; Heating;

DOI:10.1248/cpb.37.336

Reference yield: 86.0%

9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N6-benzoyladenine (109303-87-9) → 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (20187-82-0,20227-41-2,64183-27-3,123334-75-8)

Guidance literature:

With sodium methylate; for 5h; Heating;

DOI:10.1248/cpb.37.336

Reference yield:

9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N6-benzoyladenine (109303-87-9) → 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)hypoxanthine (98983-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / 1M NaOMe / 5 h / Heating

2: NaNO₂ / aq. acetic acid / 48 h

With sodium methylate; sodium nitrite; In acetic acid;

DOI:10.1248/cpb.37.336

upstream raw materials:

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide

N-benzoyladenine

Downstream raw materials:

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)hypoxanthine