6-BroMo-4,7-diMethyl-2,3-dihydro-1H-inden-1-one

Base Information

• Chemical Name: 6-BroMo-4,7-diMethyl-2,3-dihydro-1H-inden-1-one
• CAS No.: 952303-57-0
• Molecular Formula: C₁₁H₁₁BrO
• Molecular Weight: 239.112
• Mol file: 952303-57-0.mol

Synonyms:6-bromo-4,7-dimethylindan-1-one

Chemical Property of 6-BroMo-4,7-diMethyl-2,3-dihydro-1H-inden-1-one

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

6-Bromo-4,7-dimethyl-2,3-dihydro-1H-inden-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-4,7-diMethyl-2,3-dihydro-1H-inden-1-one

There total 6 articles about 6-BroMo-4,7-diMethyl-2,3-dihydro-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-(4-bromo-2,5-dimethylphenyl)propionic acid (900027-21-6) → 6-bromo-4,7-dimethylindan-1-one (952303-57-0)

Guidance literature:

With PPA; at 100 ℃; for 2.5h;

DOI:10.1021/jo070774z

Reference yield:

2-(4-bromo-2,5-dimethylbenzyl)malonic acid diethyl ester (952303-56-9) → 6-bromo-4,7-dimethylindan-1-one (952303-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / H₂O / 5 h / Heating

1.2: 83 percent / sulfuric acid / H₂O / 20 h / Heating

2.1: 88 percent / polyphosphoric acid / 2.5 h / 100 °C

With potassium hydroxide; PPA; In water;

DOI:10.1021/jo070774z

Reference yield:

2,5-dibromo-p-xylene (1074-24-4) → 6-bromo-4,7-dimethylindan-1-one (952303-57-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: n-butyl lithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

1.2: 99 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 99 percent / sodium borohydride / ethanol / 1 h / 0 - 20 °C

3.1: 93 percent / thionyl chloride / CHCl₃ / 0 - 20 °C

4.1: sodium hydride / 1,2-dimethoxy-ethane; various solvent(s) / 2 h / 20 °C

4.2: 88 percent / 1,2-dimethoxy-ethane; various solvent(s) / 12 h / Heating

5.1: potassium hydroxide / H₂O / 5 h / Heating

5.2: 83 percent / sulfuric acid / H₂O / 20 h / Heating

6.1: 88 percent / polyphosphoric acid / 2.5 h / 100 °C

With potassium hydroxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; PPA; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; chloroform; water;

DOI:10.1021/jo070774z

upstream raw materials:

3-(4-bromo-2,5-dimethylphenyl)propionic acid

2-(4-bromo-2,5-dimethylbenzyl)malonic acid diethyl ester

2,5-dibromo-p-xylene

bromo-4 dimethyl-2,5 benzaldehyde

Downstream raw materials:

C₁₈H₁₆N₄O

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