Technology Process of 3-(4-bromo-2,5-dimethylphenyl)propionic acid
There total 5 articles about 3-(4-bromo-2,5-dimethylphenyl)propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(4-bromo-2,5-dimethylbenzyl)malonic acid diethyl ester;
With
potassium hydroxide;
In
water;
for 5h;
Heating;
With
sulfuric acid;
In
water;
for 20h;
Further stages.;
Heating;
DOI:10.1021/jo070774z
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyl lithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
1.2: 99 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 99 percent / sodium borohydride / ethanol / 1 h / 0 - 20 °C
3.1: 93 percent / thionyl chloride / CHCl3 / 0 - 20 °C
4.1: sodium hydride / 1,2-dimethoxy-ethane; various solvent(s) / 2 h / 20 °C
4.2: 88 percent / 1,2-dimethoxy-ethane; various solvent(s) / 12 h / Heating
5.1: potassium hydroxide / H2O / 5 h / Heating
5.2: 83 percent / sulfuric acid / H2O / 20 h / Heating
With
potassium hydroxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; sodium hydride;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; chloroform; water;
DOI:10.1021/jo070774z
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 93 percent / thionyl chloride / CHCl3 / 0 - 20 °C
2.1: sodium hydride / 1,2-dimethoxy-ethane; various solvent(s) / 2 h / 20 °C
2.2: 88 percent / 1,2-dimethoxy-ethane; various solvent(s) / 12 h / Heating
3.1: potassium hydroxide / H2O / 5 h / Heating
3.2: 83 percent / sulfuric acid / H2O / 20 h / Heating
With
potassium hydroxide; thionyl chloride; sodium hydride;
In
1,2-dimethoxyethane; chloroform; water;
DOI:10.1021/jo070774z
