Technology Process of 2-(4-bromo-2,5-dimethylbenzyl)malonic acid diethyl ester
There total 4 articles about 2-(4-bromo-2,5-dimethylbenzyl)malonic acid diethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl malonate;
With
sodium hydride;
In
1,2-dimethoxyethane;
at 20 ℃;
for 2h;
4-bromo-2,5-dimethylbenzyl chloride;
In
1,2-dimethoxyethane;
for 12h;
Further stages.;
Heating;
DOI:10.1021/jo070774z
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyl lithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
1.2: 99 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 99 percent / sodium borohydride / ethanol / 1 h / 0 - 20 °C
3.1: 93 percent / thionyl chloride / CHCl3 / 0 - 20 °C
4.1: sodium hydride / 1,2-dimethoxy-ethane; various solvent(s) / 2 h / 20 °C
4.2: 88 percent / 1,2-dimethoxy-ethane; various solvent(s) / 12 h / Heating
With
sodium tetrahydroborate; n-butyllithium; thionyl chloride; sodium hydride;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; chloroform;
DOI:10.1021/jo070774z
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 99 percent / sodium borohydride / ethanol / 1 h / 0 - 20 °C
2.1: 93 percent / thionyl chloride / CHCl3 / 0 - 20 °C
3.1: sodium hydride / 1,2-dimethoxy-ethane; various solvent(s) / 2 h / 20 °C
3.2: 88 percent / 1,2-dimethoxy-ethane; various solvent(s) / 12 h / Heating
With
sodium tetrahydroborate; thionyl chloride; sodium hydride;
In
1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1021/jo070774z
