methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

Base Information

Chemical Name:methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate
CAS No.:196860-94-3
Molecular Formula:C₃₁H₄₀N₂O₈Si
Molecular Weight:596.753
Hs Code.:

Synonyms:methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

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Chemical Property of methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

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Technology Process of methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

There total 7 articles about methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 142602-45-7
2-(trimethylsilyl)ethyl α-(dimethoxyphosphoryl)-N-(tert-butyloxycarbonyl)glycinate

: 196860-93-2
methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate

: 196860-94-3
methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

Guidance literature:: 2-(trimethylsilyl)ethyl α-(dimethoxyphosphoryl)-N-(tert-butyloxycarbonyl)glycinate; With 1,1,3,3-tetramethylguanidine; In dichloromethane; at 20 ℃; for 0.5h;

methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate; In dichloromethane; for 24h;
DOI:10.1021/jo971077h

Reference yield:

: Phosphorylglycinate

: 142602-45-7
2-(trimethylsilyl)ethyl α-(dimethoxyphosphoryl)-N-(tert-butyloxycarbonyl)glycinate

: 196860-93-2
methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate

: 196860-94-3
methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

Guidance literature:: With N,N,N₁,N₁-tetramethylguanidine; In dichloromethane;

Reference yield:

: 626-19-7
Isophthalaldehyde

: 196860-94-3
methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetramethylguanidine / CH₂Cl₂ / 0.5 h

1.2: 94 percent / CH₂Cl₂ / 0.17 h

2.1: tetramethylguanidine / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 83 percent / CH₂Cl₂ / 24 h

With 1,1,3,3-tetramethylguanidine; In dichloromethane; 1.1: deprotonation / 1.2: Horner-Wittig coupling / 2.1: deprotonation / 2.2: Horner-Wittig coupling;
DOI:10.1021/jo971077h