methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate

Base Information

• Chemical Name: methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate
• CAS No.: 196860-93-2
• Molecular Formula: C₁₉H₁₇NO₅
• Molecular Weight: 339.348
• Mol file: 196860-93-2.mol

Synonyms:methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate

Chemical Property of methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate

There total 2 articles about methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Isophthalaldehyde (626-19-7) + N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate (196860-93-2)

Guidance literature:

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester; With 1,1,3,3-tetramethylguanidine; In dichloromethane; for 0.5h;

Isophthalaldehyde; In dichloromethane; for 0.166667h;

DOI:10.1021/jo971077h

Reference yield:

Phosphorylglycinate + Isophthalaldehyde (626-19-7) + N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate (196860-93-2)

Guidance literature:

With N,N,N₁,N₁-tetramethylguanidine; In dichloromethane;

Reference yield: 83.0%

2-(trimethylsilyl)ethyl α-(dimethoxyphosphoryl)-N-(tert-butyloxycarbonyl)glycinate (142602-45-7) + methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate (196860-93-2) → methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate (196860-94-3)

Guidance literature:

2-(trimethylsilyl)ethyl α-(dimethoxyphosphoryl)-N-(tert-butyloxycarbonyl)glycinate; With 1,1,3,3-tetramethylguanidine; In dichloromethane; at 20 ℃; for 0.5h;

methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-(3-formylphenyl)-2-propenoate; In dichloromethane; for 24h;

DOI:10.1021/jo971077h

upstream raw materials:

Isophthalaldehyde

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

Downstream raw materials:

methyl (Z)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(Z)-2-[(tert-butoxycarbonyl)amino]-3-[2-(trimethylsilyl)ethoxy]-3-oxo-1-propenyl]phenyl]-2-propenoate

(S)-2-Amino-3-{3-[(S)-2-tert-butoxycarbonylamino-2-(carboxymethyl-carbamoyl)-ethyl]-phenyl}-propionic acid methyl ester

methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate

methyl (S)-2-[[(benzyloxy)carbonyl]amino]-3-[3-[(S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenyl]propanoate