benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate

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Chemical Name:benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate
CAS No.:1357182-35-4
Molecular Formula:C₄₄H₄₄N₄O₆S
Molecular Weight:756.923
Hs Code.:

Synonyms:benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate

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Chemical Property of benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate

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Technology Process of benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate

There total 9 articles about benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1331748-08-3
benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(piperidin-4-ylmethyl)acetamido)benzoate

: 1357182-35-4
benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere;

Reference yield:

: 28126-01-4
methyl 2-(N,4-dimethylphenylsulfonam ido)acetate

: 1357182-35-4
benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

2: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; dimethyl sulfoxide;
DOI:10.1002/cmdc.201100194

Reference yield:

: 2645-02-5
methyl tosylglycinate

: 1357182-35-4
benzyl 2-(benzyloxy)-4-(N-((1-(4-cyanophenyl)piperidin-4-yl)methyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

3: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100194