Technology Process of Cyclobutanecarboxylic acid, 1-methyl-3-oxo-, ethyl ester (9CI)
There total 8 articles about Cyclobutanecarboxylic acid, 1-methyl-3-oxo-, ethyl ester (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 1-methyl-3-methylenecyclobutanecarboxylate;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
With
dimethylsulfide;
In
dichloromethane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: water; potassium hydroxide / ethanol / Reflux; Inert atmosphere
3.1: thionyl chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere
3.2: 0.5 h / 0 °C / Inert atmosphere
4.1: dichloromethane / 16 h / 20 °C / Inert atmosphere
5.1: ozone / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
5.2: 0.5 h / -78 °C / Inert atmosphere
With
thionyl chloride; water; ozone; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane;
- Guidance literature:
-
ethyl 2-methyl-5,8-dioxaspiro[3.4]octane-2-carboxylate;
With
hydrogenchloride;
In
water; acetone;
at 20 ℃;
for 96h;
With
oxalyl dichloride;
N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 2h;
With
ethanol;
In
dichloromethane;
for 1h;
