N-Cbz-GABOB methyl ester

Base Information

• Chemical Name: N-Cbz-GABOB methyl ester
• CAS No.: 119960-08-6
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.282
• Mol file: 119960-08-6.mol

Synonyms:N-Cbz-GABOB methyl ester

Chemical Property of N-Cbz-GABOB methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Cbz-GABOB methyl ester

There total 2 articles about N-Cbz-GABOB methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 4-<(benzyloxycarbonyl)amino>-3-oxobutanoate (82961-77-1) → N-Cbz-GABOB methyl ester (119960-08-6)

Guidance literature:

In ethanol; water; for 16h; Ambient temperature; baker's yeast / saccharose;

DOI:10.1055/s-1992-26123

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-Cbz-GABOB methyl ester (119960-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CDI (1,1'-carbonyldiimidazole) / 1.) THF, r.t., 1 h, 2.) THF, r.t., 14 h

2: 88 percent / ethanol; H₂O / 16 h / Ambient temperature; baker's yeast / saccharose

With 1,1'-carbonyldiimidazole; In ethanol; water;

DOI:10.1055/s-1992-26123

Reference yield: 82.0%

N-Cbz-GABOB methyl ester (119960-08-6) → (R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid (80503-94-2,118125-41-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; for 1h; ice-cooling;

DOI:10.1055/s-1992-26123

upstream raw materials:

methyl 4-<(benzyloxycarbonyl)amino>-3-oxobutanoate

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

(R)-4-Benzyloxycarbonylamino-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-butyric acid methyl ester

(R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid