82961-77-1

Usage

Uses

Used in Pharmaceutical Research:
3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER is used as a building block for the synthesis of pharmaceuticals and other biologically active compounds. Its versatile chemical properties make it a valuable component in the development of new drugs.
Used in Neurological Disorder Treatment:
3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER is studied for its potential use in the treatment of neurological disorders. Its connection to GABA, an important neurotransmitter, suggests it may have therapeutic effects on conditions related to neurotransmission.
Used in Synthesis of GABA Analogs:
3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER is used as a precursor in the synthesis of GABA analogs. These analogs can be further explored for their potential applications in medicine and pharmacology, expanding the range of treatments available for various conditions.
Used in Chemical Research:
3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER is utilized in chemical research to study its properties and reactions, contributing to the broader understanding of organic chemistry and its applications.

Upstream product

• 67-56-1 methanol 
• 82961-72-6 5-(N-Z-glycyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 38330-80-2 monomethyl monopotassium malonate 
• 22586-32-9 N-Benzyloxycarbonylglycine imidazolide 
• 57907-72-9 Methyl hydrogen malonate dianion magnesium chelate 

Downstream Products

• 1361254-00-3 (10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracen-8-ylmethyl)carbamic acid benzyl ester 
• 161971-54-6 methyl (RS)-<4-(benzyloxycarbonyl)amino>-3-hydroxybutyrate 
• 141734-41-0 (R)-4-Benzyloxycarbonylamino-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-butyric acid methyl ester 
• 80503-94-2 (R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 
• 119960-08-6 N-Cbz-GABOB methyl ester 

Relevant academic research and scientific papers

Synthesis of novel 3D-rich α-amino acid-derived 3-pyrazolidinones

Synthetic approaches towards novel 3-pyrazolidinone derivatives functionalized at positions N(1) and/or C(5) were studied. 5-Aminoalkyl-3-pyrazolidinones were prepared in four steps from N-protected glycines via Masamune-Claisen homologation, reduction, O

A mild titanium-catalyzed synthesis of functionalized amino coumarins as fluorescence labels

In contrast to Bronsted and other Lewis acids ClTi(OiPr)3 is especially suited to catalyze the formation of amino-substituted coumarins from aminophenols and functionalized β-oxo esters in a Pechmann condensation. This straightforward protocol allows the synthesis of fluorescence labels and false fluorescent neurotransmitters.

Chain extension of amino acid skeletons: Preparation of ketomethylene isosteres

Ketomethylene isosteric replacements for peptide bonds were generated through a zinc carbenoid-mediated chain extension reaction in which a variety of amino acid-derived β-keto esters are converted to γ-keto esters in a single step. The reaction tolerates a variety of protecting groups and amino acid side chains with no epimerization of the amino acid stereocenter.

Process for preparing optically active 4-hydroxy-2-pyrrolidone

A process for preparing optically active 4-hydroxy-2-pyrrolidone comprising asymmetrically hydrogenating an N-substituted-4-amino-3-oxobutanoic ester represented by formula (I): STR1 wherein R1 represents a benzyloxycarbonyl group, the benzene

Baker's yeast reduction of N-protected methyl 4-amino-3-oxobutanoates and 3-oxopentanoates

Baker's yeast reduction of N-tert-butoxycarbonyl (Boc) or N-benzyloxycarbonyl (Cbz) protected methyl 4-amino-3-oxopentanoates 4b-e and 4-amino-3-oxobutanoates 7a,b stereoselectively afforded the erythro-hydroxy esters 5b-e and (R)-hydroxy esters 8a,b, res

Intramolecular N-H, O-H, and S-H Insertion Reactions. Synthesis of Heterocycles from α-Diazo β-Keto Esters

Several aspects of the Rh2(OAc)4-catalyzed intramolecular N-H, O-H, and S-H insertion reactions have been studied.Examination of the effect of ring size revealed that four-, five- and six-membered nitrogen heterocycles can be efficiently prepared from the corresponding α-diazo β-keto ester precursors (9a-c), whereas competing C-H insertion prevented formation of the seven-membered heterocycle.Variations in solvent, temperature, and catalyst concentration were found to play an important role in determining the product distribution in the cyclization of the 6-carbamoyl 2-diazo 3-keto ester 9c.The intramolecular X-H insertion reaction has also been successful in the synthesis of oxygen (39) and sulfur (49) heterocycles as well as a heterocycle containing two (N, O) heteroatoms (34).