82961-77-1Relevant articles and documents
Synthesis of novel 3D-rich α-amino acid-derived 3-pyrazolidinones
Glava?, Jaka,Dahmann, Georg,Po?gan, Franc,Ri?ko, Sebastijan,?tefane, Bogdan,Svete, Jurij,Gro?elj, Uro?
, p. 715 - 726 (2018/01/17)
Synthetic approaches towards novel 3-pyrazolidinone derivatives functionalized at positions N(1) and/or C(5) were studied. 5-Aminoalkyl-3-pyrazolidinones were prepared in four steps from N-protected glycines via Masamune-Claisen homologation, reduction, O
Chain extension of amino acid skeletons: Preparation of ketomethylene isosteres
Theberge, Cory R.,Zercher, Charles K.
, p. 1521 - 1527 (2007/10/03)
Ketomethylene isosteric replacements for peptide bonds were generated through a zinc carbenoid-mediated chain extension reaction in which a variety of amino acid-derived β-keto esters are converted to γ-keto esters in a single step. The reaction tolerates a variety of protecting groups and amino acid side chains with no epimerization of the amino acid stereocenter.
Baker's yeast reduction of N-protected methyl 4-amino-3-oxobutanoates and 3-oxopentanoates
Hashiguchi,Kawada,Natsugari
, p. 403 - 408 (2007/10/02)
Baker's yeast reduction of N-tert-butoxycarbonyl (Boc) or N-benzyloxycarbonyl (Cbz) protected methyl 4-amino-3-oxopentanoates 4b-e and 4-amino-3-oxobutanoates 7a,b stereoselectively afforded the erythro-hydroxy esters 5b-e and (R)-hydroxy esters 8a,b, res