1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate
• CAS No.: 1244740-07-5
• Molecular Formula: C₁₇H₂₅N₃O₃
• Molecular Weight: 319.404
• Mol file: 1244740-07-5.mol

Synonyms:1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

Chemical Property of 1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

There total 1 articles about 1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

phenyl isocyanate (103-71-9) + (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (147081-29-6) → 1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate (1244740-07-5)

Guidance literature:

phenyl isocyanate; (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

With hydrogenchloride; In water;

Reference yield:

1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate (1244740-07-5) → (2S)-2-methyl-N-phenyl-1-piperazinecarboxamide hydrochloride (1244740-57-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h;

Reference yield:

1,1-dimethylethyl (3S)-3-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate (1244740-07-5) → C12H17N3O

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

DOI:10.1002/cmdc.201800739

upstream raw materials:

phenyl isocyanate

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(2S)-2-methyl-N-phenyl-1-piperazinecarboxamide hydrochloride