4-Chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile

Base Information

Chemical Name:4-Chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile
CAS No.:214470-72-1
Molecular Formula:C13H10Cl2N2O2
Molecular Weight:297.141
Hs Code.:
DSSTox Substance ID:DTXSID401183029

Synonyms:214470-72-1;4-chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile;3-Quinolinecarbonitrile, 4-chloro-7-(2-chloroethoxy)-6-methoxy-;3-Quinolinecarbonitrile,4-chloro-7-(2-chloroethoxy)-6-methoxy-;SCHEMBL2977174;GAOYRWYHERKJQE-UHFFFAOYSA-N;DTXSID401183029;7-(2-chloro-ethoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile

Suppliers and Price of 4-Chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-Chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:457.259°C at 760 mmHg
Flash Point:230.342°C
PSA：55.14000
Density:1.412g/cm³
LogP:3.38608
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:296.0119330
Heavy Atom Count:19
Complexity:347

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=C(C=N2)C#N)Cl)OCCCl

Technology Process of 4-Chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile

There total 10 articles about 4-Chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 263149-10-6
4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile

: 107-07-3
2-chloro-ethanol

: 214470-72-1
4-chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 0.25h;
DOI:10.1021/jm0102250

Reference yield:

: 214470-61-8
7-(2-Chloro-ethoxy)-4-hydroxy-6-methoxy-quinoline-3-carbonitrile

: 214470-72-1
4-chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrile

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2.5h; Heating / reflux; Alkaline aqueous solution;