(S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

Base Information

Chemical Name:(S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one
CAS No.:170508-79-9
Molecular Formula:C₃₂H₃₈N₂O₁₁
Molecular Weight:626.661
Hs Code.:

Synonyms:(S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

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Chemical Property of (S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

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Technology Process of (S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

There total 8 articles about (S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 5-[(S)-3-(2'-Hydroxy-[1,1']binaphthalenyl-2-yloxycarbonylmethyl)-4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

: 170508-79-9
(S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: With sodium methylate; In tetrahydrofuran; for 0.416667h; Ambient temperature;
DOI:10.1039/p19960002091

Reference yield: 93.0%

: 67-56-1
methanol

: 183061-68-9
(S)-3-[(3R,4R,5R)-4,5-((R)-Benzylidenedioxy)-2-oxotetrahydropyran-3-yloxycarbonylmethyl]-9-benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

: 170508-79-9
(S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: With sodium methylate; In tetrahydrofuran; for 0.416667h; Ambient temperature;
DOI:10.1039/p19960002091

Reference yield:

: 50622-67-8
5-acetoxymethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester

: 170508-79-9
(S)-9-Benzyloxycarbonyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4-methyl-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) SnCl₄, 2.) aq. p-TsOH, AgOAc / 1.) CH₂Cl₂, -78 deg C to 0 deg C, 3 h, 2.) THF, 13 h

2: 64 percent / TBAF*3H₂O / tetrahydrofuran / 0.67 h / Ambient temperature

3: 1-chloro-1-dimethylamino-2-methylpropene / CH₂Cl₂ / 0.17 h

4: CH₂Cl₂ / 6 h

5: 100 percent / NaOMe / tetrahydrofuran / 0.42 h / Ambient temperature

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; tetrabutyl ammonium fluoride; sodium methylate; silver(I) acetate; tin(IV) chloride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/p19960002091