Ethyl 3-(2-furyl)pyrazole-5-carboxylate, 98%

Base Information

• Chemical Name: Ethyl 3-(2-furyl)pyrazole-5-carboxylate, 98%
• CAS No.: 33545-44-7
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.201
• Mol file: 33545-44-7.mol

Synonyms:Pyrazole-3(or5)-carboxylic acid, 5(or 3)-(2-furyl)-, ethyl ester (6CI);Pyrazole-3-carboxylic acid, 5-(2-furyl)-, ethyl ester (8CI)

Chemical Property of Ethyl 3-(2-furyl)pyrazole-5-carboxylate, 98%

Chemical Property:

• Vapor Pressure: 1.04E-06mmHg at 25°C
• Melting Point: 135-137°C
• Refractive Index: 1.545
• Boiling Point: 403.1°Cat760mmHg
• Flash Point: 197.6°C
• PSA: 68.12000
• Density: 1.263g/cm³
• LogP: 1.84640

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-3-(2-FURYL)PYRAZOLE-5-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-(2-furyl)pyrazole-5-carboxylate, 98%

There total 6 articles about Ethyl 3-(2-furyl)pyrazole-5-carboxylate, 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(Z)-1,1,1-Trichloro-4-furan-2-yl-4-methoxy-but-3-en-2-one + ethanol (64-17-5) → ethyl 3(5)-(2-furyl)-pyrazole-5(3)-carboxylate (33545-44-7)

Guidance literature:

With hydrazine hydrate; for 2h;

DOI:10.1055/s-2005-872140

Reference yield: 81.0%

3-furan-2-yl-5-trichloromethyl-1H-pyrazole (871239-83-7) + ethanol (64-17-5) → ethyl 3(5)-(2-furyl)-pyrazole-5(3)-carboxylate (33545-44-7)

Guidance literature:

With hydrogenchloride; at 35 ℃; for 2h;

DOI:10.1055/s-2005-872140

Reference yield: 75.0%

ethyl 4-(furan-2-yl)-2,4-dioxobutyrate (36983-35-4) → ethyl 3(5)-(2-furyl)-pyrazole-5(3)-carboxylate (33545-44-7)

Guidance literature:

With hydrazine; In tetrahydrofuran; ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201300901

upstream raw materials:

4-furan-2-yl-4-oxo-but-2-ynoic acid ethyl ester

ethanol

3-furan-2-yl-5-trichloromethyl-1H-pyrazole

ethyl 4-(furan-2-yl)-2,4-dioxobutyrate

Downstream raw materials:

3(5)-hydroxymethyl-5(3)-(2-furyl)pyrazole