5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
CAS No.:296802-65-8
Molecular Formula:C₄₄H₅₁N₆O₈P
Molecular Weight:822.898
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.9%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 296802-64-7
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine

: 296802-65-8
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Guidance literature:: With N,N-diisopropylamine tetrazolide; In acetonitrile;
DOI:10.1021/jm0203276

Reference yield:

: 2140-79-6
2'-O-methyl adenosine

: 296802-65-8
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: 80.4 percent / aq. acetic acid; NaNO₂

2: 75.2 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-acetamide / 18 h / 20 °C

3: 36.5 percent / pyridine / 6 h

4: 81.9 percent / diisopropylammonium tetrazolide / acetonitrile

With pyridine; N,N-diisopropylamine tetrazolide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium nitrite; In N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/jm0203276

Reference yield:

: 3881-21-8
2'-O-methylinosine

: 296802-65-8
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-1-propargylinosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 75.2 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-acetamide / 18 h / 20 °C

2: 36.5 percent / pyridine / 6 h

3: 81.9 percent / diisopropylammonium tetrazolide / acetonitrile

With pyridine; N,N-diisopropylamine tetrazolide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/jm0203276