methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

Base Information

Chemical Name:methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate
CAS No.:134162-81-5
Molecular Formula:C₂₂H₂₉ClN₂O₄S
Molecular Weight:453.002
Hs Code.:

Synonyms:methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

Suppliers and Price of methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

There total 10 articles about methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 134162-88-2
methyl 8-amino-5-<2-(3-pyridinyl)ethyl>octanoate

: 134162-81-5
methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00101a014

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 134162-81-5
methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 64 percent / Et₃N, Pd(OAc)2, tri-o-tolylphosphine / acetonitrile / 20 h / 125 °C

2: 99 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / 2 h / 0 °C

3: 100 percent / CH₂Cl₂ / 16 h / Ambient temperature

4: 62 percent / H₂ / 10percent Pd/C / ethanol / 21 h / 2327.2 Torr / Ambient temperature

5: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

6: CH₂Cl₂; dimethylsulfoxide / 18.5 h / Ambient temperature

7: 100 percent / H₂, NH₃ / Raney Ni / methanol; NH₃; H₂O / 4 h / 2585.7 Torr / Ambient temperature

8: 41 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; palladium diacetate; ammonia; hydrogen; diisobutylaluminium hydride; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; nickel; In methanol; ethanol; dichloromethane; ammonia; water; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm00101a014

Reference yield:

: 3393-45-1
5,6-dihydro-pyran-2-one

: 134162-81-5
methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-5-<2-(3-pyridinyl)ethyl>octanoate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) CuCN / 1.) PhMe, Et₂O, 0 deg C, 2 min, 2.) PhMe, Et₂O, from -78 deg C to -20 deg C, 45 min

2: 64 percent / Et₃N, Pd(OAc)2, tri-o-tolylphosphine / acetonitrile / 20 h / 125 °C

3: 99 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / 2 h / 0 °C

4: 100 percent / CH₂Cl₂ / 16 h / Ambient temperature

5: 62 percent / H₂ / 10percent Pd/C / ethanol / 21 h / 2327.2 Torr / Ambient temperature

6: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

7: CH₂Cl₂; dimethylsulfoxide / 18.5 h / Ambient temperature

8: 100 percent / H₂, NH₃ / Raney Ni / methanol; NH₃; H₂O / 4 h / 2585.7 Torr / Ambient temperature

9: 41 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; palladium diacetate; ammonia; hydrogen; diisobutylaluminium hydride; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; nickel; In methanol; ethanol; dichloromethane; ammonia; water; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm00101a014