2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide

Base Information

Chemical Name:2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide
CAS No.:1427406-98-1
Molecular Formula:C₂₀H₁₄F₃NO₂
Molecular Weight:357.332
Hs Code.:

Synonyms:2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide

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Chemical Property of 2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide

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Technology Process of 2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide

There total 4 articles about 2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427406-97-0
3-amino-2-fluoro-4-methylphenol

: 1427406-98-1
2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 1178958-75-2
2-fluoro-5-(3-fluorophenyl)benzoic acid

: 1427406-98-1
2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / 65 °C / Inert atmosphere

2: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 0 - 20 °C

With thionyl chloride; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 146328-85-0
5-bromo-2-fluoro-benzoic acid

: 1427406-98-1
2-fluoro-N-(2-fluoro-3-hydroxy-6-methylphenyl)-5-(3-fluorophenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: thionyl chloride / 1 h / 65 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;