isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

Base Information

Chemical Name:isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate
CAS No.:1415230-92-0
Molecular Formula:C₁₉H₂₃ClN₂O₄
Molecular Weight:378.856
Hs Code.:

Synonyms:isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

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Technology Process of isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

There total 2 articles about isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 106-63-8,26335-74-0
isobutyl acrylate

: 1412907-25-5
1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-yl acetate

: 1415230-92-0
isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-08-1
diisobutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.09.096

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1415230-92-0
isobutyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 24 h / 60 °C / Reflux

2: 12 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; 3: |Michael Addition;
DOI:10.1016/j.tetlet.2012.09.096