C₃₆H₄₆N₂O₉

Base Information

• Chemical Name: C₃₆H₄₆N₂O₉
• CAS No.: 1308253-70-4
• Molecular Formula: C₃₆H₄₆N₂O₉
• Molecular Weight: 650.769
• Mol file: 1308253-70-4.mol

Synonyms:C₃₆H₄₆N₂O₉

Chemical Property of C₃₆H₄₆N₂O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₄₆N₂O₉

There total 8 articles about C₃₆H₄₆N₂O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-tert-butoxycarbonylamino-3-(3-hydroxy-4-methoxy-5-methyl-phenyl)-propionic acid + (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol (1218781-83-9) → C36H46N2O9 (1308253-70-4)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/jhet.609

Reference yield:

(S)-methyl-2-acetamido-3-(3-formyl-4-methoxy-3-methylphenyl)propanoate (1177255-27-4) → C36H46N2O9 (1308253-70-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 20 °C

2: hydrogenchloride; water / methanol / 10 h

3: lithium borohydride / tetrahydrofuran / 24 h

4: hydrogenchloride / methanol; water / 6 h / Reflux

5: acetic acid / dichloromethane; 2,2,2-trifluoroethanol / 9 h / -10 °C / Molecular sieve

6: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; lithium borohydride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; 2,2,2-trifluoroethanol; water; 1: Baeyer-Villiger oxidation;

DOI:10.1002/jhet.609

Reference yield:

(S)-methyl-2-acetamido-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoate (1177255-28-5) → C36H46N2O9 (1308253-70-4)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran / 24 h

2: hydrogenchloride / methanol; water / 6 h / Reflux

3: acetic acid / dichloromethane; 2,2,2-trifluoroethanol / 9 h / -10 °C / Molecular sieve

4: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; lithium borohydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 2,2,2-trifluoroethanol; water;

DOI:10.1002/jhet.609

upstream raw materials:

(1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol

(S)-methyl-2-acetamido-3-(3-formyl-4-methoxy-3-methylphenyl)propanoate

(S)-methyl-2-acetamido-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoate

C₁₃H₁₉NO₄

Downstream raw materials:

C₄₈H₇₂N₂O₉Si₂

C₃₆H₄₄N₂O₉

C₄₈H₇₄N₂O₉Si₂

C₅₄H₈₈N₂O₉Si₃