5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride

Base Information

• Chemical Name: 5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride
• CAS No.: 1573008-93-1
• Molecular Formula: C₈H₄BrCl₂FO₃S
• Molecular Weight: 349.992
• Mol file: 1573008-93-1.mol

Synonyms:5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride

Chemical Property of 5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride

There total 3 articles about 5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoic acid (1572516-10-9) → 5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride (1573008-93-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

2-fluoro-6-methylbenzoic acid (90259-27-1) → 5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride (1573008-93-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; nitric acid / 15 °C

1.2: 4 h / 15 - 20 °C

2.1: chlorosulfonic acid / 5 h / 115 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2.5 h / 20 °C

With chlorosulfonic acid; oxalyl dichloride; nitric acid; acetic acid; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

3-bromo-6-fluoro-2-methyl-benzoic acid (1427373-55-4) → 5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoyl chloride (1573008-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 5 h / 115 °C

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2.5 h / 20 °C

With chlorosulfonic acid; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

2-fluoro-6-methylbenzoic acid

3-bromo-6-fluoro-2-methyl-benzoic acid

5-bromo-3-(chlorosulfonyl)-2-fluoro-6-methylbenzoic acid

Downstream raw materials:

5-bromo-3-[(3-chloro-4,5-difluorophenyl)carbamoyl]-2-fluoro-4-methylbenzenesulfonyl chloride

N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide

5-bromo-N-(3-chloro-4,5-difluorophenyl)-2-fluoro-6-methyl-3-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]benzamide