5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

Base Information

Chemical Name:5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid
CAS No.:923595-10-2
Molecular Formula:C₁₅H₁₅BO₄
Molecular Weight:270.093
Hs Code.:

Synonyms:5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

Suppliers and Price of 5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

There total 4 articles about 5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 923595-07-7
4-methyl-1-(2,2-dimethoxy-2-phenyl-ethoxy)-2-iodobenzene

: 923595-10-2
5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

Guidance literature:: 4-methyl-1-(2,2-dimethoxy-2-phenyl-ethoxy)-2-iodobenzene; With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃;

With Trimethyl borate; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃;

With sulfuric acid; In methanol; at 20 ℃; Further stages.;
DOI:10.1016/j.tet.2008.05.056

Reference yield:

: 2-(4-chloro-2-iodophenoxy)-1-phenylethan-1-one

: 923595-10-2
5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: p-toluenesulfonic acid / methanol / 50 °C

2.1: n-BuLi / tetrahydrofuran; diethyl ether; hexane / -78 °C

2.2: B(OMe)3 / tetrahydrofuran; diethyl ether; hexane / -78 - 20 °C

2.3: aq. HCl / tetrahydrofuran; diethyl ether; hexane / 20 °C

3.1: aq. H₂SO₄ / methanol / 20 °C

With n-butyllithium; sulfuric acid; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; hexane;
DOI:10.1021/ja0672425

Reference yield:

: 71643-66-8
4-chloro-2-iodo phenol

: 923595-10-2
5-methyl-2-(2-oxo-2-phenylethoxy)-phenyl boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / acetone / Heating

2.1: p-toluenesulfonic acid / methanol / 50 °C

3.1: n-BuLi / tetrahydrofuran; diethyl ether; hexane / -78 °C

3.2: B(OMe)3 / tetrahydrofuran; diethyl ether; hexane / -78 - 20 °C

3.3: aq. HCl / tetrahydrofuran; diethyl ether; hexane / 20 °C

4.1: aq. H₂SO₄ / methanol / 20 °C

With n-butyllithium; sulfuric acid; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; hexane; acetone;
DOI:10.1021/ja0672425