4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide

Base Information

Chemical Name:4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide
CAS No.:1314126-81-2
Molecular Formula:C₂₆H₃₃N₃O₄S
Molecular Weight:483.632
Hs Code.:

Synonyms:4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide

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Chemical Property of 4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide

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Technology Process of 4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide

There total 4 articles about 4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1314129-42-4
2-methyl-2-(methylsulfonyl)propan-1-amine hydrochloride

: 1314127-95-1
4-(cyclopropylmethoxy)-N-(2-formyl-1-methyl-1H-indol-5-yl)benzamide

: 1314126-81-2
4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide

Guidance literature:: 2-methyl-2-(methylsulfonyl)propan-1-amine hydrochloride; 4-(cyclopropylmethoxy)-N-(2-formyl-1-methyl-1H-indol-5-yl)benzamide; With triethylamine; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.5h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1314127-94-0
ethyl 5-({[4-(cyclopropylmethoxy)phenyl]carbonyl}amino)-1-methyl-1H-indole-2-carboxylate

: 1314126-81-2
4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

1.2: 2 h / Reflux

2.1: triethylamine / acetic acid / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h

2.2: 20 °C

With lithium aluminium tetrahydride; triethylamine; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 71056-58-1
5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester

: 1314126-81-2
4-(cyclopropylmethoxy)-N-[1-methyl-2-({[2-methyl-2-(methylsulfonyl)propyl]amino)methyl)-1H-indol-5-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dmap / N,N-dimethyl-formamide / 17 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

2.2: 2 h / Reflux

3.1: triethylamine / acetic acid / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h

3.2: 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;