2-Chloro-6-methoxy-N,N-dimethylbenzenemethanamine

Base Information

• Chemical Name: 2-Chloro-6-methoxy-N,N-dimethylbenzenemethanamine
• CAS No.: 83781-50-4
• Molecular Formula: C₁₀H₁₄ClNO
• Molecular Weight: 199.68
• DSSTox Substance ID: DTXSID801234585
• Mol file: 83781-50-4.mol

Synonyms:2-Chloro-6-methoxy-N,N-dimethylbenzenemethanamine;83781-50-4;DTXSID801234585

Chemical Property of 2-Chloro-6-methoxy-N,N-dimethylbenzenemethanamine

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 199.0763918
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC1=C(C=CC=C1Cl)OC

Technology Process of 2-Chloro-6-methoxy-N,N-dimethylbenzenemethanamine

There total 2 articles about 2-Chloro-6-methoxy-N,N-dimethylbenzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(2-chloro-6-methoxyphenyl)acetonitrile (83781-95-7) + dimethyl amine (124-40-3) → (2-chloro-6-methoxybenzyl)dimethylamine (83781-50-4)

Guidance literature:

In ethanol; water; for 0.25h; Ambient temperature;

DOI:10.1021/ja00390a036

Reference yield:

1-chloro-3-methoxy-2-methylbenzene (3260-88-6) → (2-chloro-6-methoxybenzyl)dimethylamine (83781-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / N-nromosuccinimide, benzoyl peroxide / CCl₄ / 12 h / Heating

2: 85 percent / ethanol; H₂O / 0.25 h / Ambient temperature

With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; ethanol; water;

DOI:10.1021/ja00390a036

Reference yield: 80.0%

(trimethylsilyl)methylmagnesium chloride (13170-43-9) + (2-chloro-6-methoxybenzyl)dimethylamine (83781-50-4) → <2-((trimethylsilyl)methyl)-6-methoxybenzyl>dimethylamine (83781-46-8)

Guidance literature:

In diethyl ether; benzene; for 36h; Ambient temperature;

DOI:10.1021/ja00390a036

upstream raw materials:

2-(2-chloro-6-methoxyphenyl)acetonitrile

dimethyl amine

1-chloro-3-methoxy-2-methylbenzene

Downstream raw materials:

<2-((trimethylsilyl)methyl)-6-methoxybenzyl>dimethylamine

2-carbomethoxy-5-methoxy-1,2,3,4-tetrahydronaphthalene

<2-((trimethylsilyl)methyl)-6-methoxybenzyl>trimethylammonium iodide