2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Base Information

• Chemical Name: 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile
• CAS No.: 1352297-90-5
• Molecular Formula: C₁₇H₁₆N₂O
• Molecular Weight: 264.327
• Mol file: 1352297-90-5.mol

Synonyms:2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Chemical Property of 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

There total 6 articles about 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trimethylsilyl cyanide (7677-24-9) + 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (1057280-33-7) → 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (1352297-90-5)

Guidance literature:

With amine functionalized Zr(IV) metal-organic framework (UiO-66-NH₂) through covalent hooking of EOSIN-Y; In methanol; at 20 ℃; for 4.2h;

DOI:10.1016/j.jcat.2019.02.011

Reference yield: 86.0%

potassium cyanide + 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (1057280-33-7) → 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (1352297-90-5)

Guidance literature:

With [Ir(tbp-py)2(bpy)]PF₆; acetic acid; In acetonitrile; for 36h; Irradiation;

DOI:10.1039/c1cc15643h

Reference yield: 84.0%

2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (1057280-33-7) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (1352297-90-5)

Guidance literature:

With copper(l) iodide; trimethylsilylazide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; at 90 ℃; for 18h; Catalytic behavior; Inert atmosphere; Molecular sieve; Schlenk technique;

DOI:10.1021/ol500045p

upstream raw materials:

2-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

1,2-dichloro-ethane

2-(3-methoxyphenyl)-3,4-dihydroisoquinolinium bromide

trimethylsilyl cyanide