2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine

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Chemical Name:2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine
CAS No.:1375182-80-1
Molecular Formula:C₁₆H₁₂FN₇S
Molecular Weight:353.383
Hs Code.:

Synonyms:2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine

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Chemical Property of 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine

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Technology Process of 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine

There total 4 articles about 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 61310-53-0
3-ethoxyacrylonitrile

: 1375183-37-1
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

: 1375182-80-1
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine

Guidance literature:: With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 110 ℃; for 46h;

Reference yield:

: 1375183-33-7
ethyl 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxylate

: 1375182-80-1
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia; sodium cyanide / methanol / 24 h / 90 °C / Sealed tube

2.1: trifluoroacetic anhydride; pyridine / 2.08 h / 0 - 20 °C

3.1: sodium methylate; methanol / 5 h / 20 °C

3.2: 17 h / 20 °C

4.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 46 h / 110 °C

With pyridine; methanol; sodium cyanide; ammonia; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; In methanol;

Reference yield:

: 1375183-34-8
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxamide

: 1375182-80-1
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic anhydride; pyridine / 2.08 h / 0 - 20 °C

2.1: sodium methylate; methanol / 5 h / 20 °C

2.2: 17 h / 20 °C

3.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 46 h / 110 °C

With pyridine; methanol; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride;