61310-53-0Relevant articles and documents
3 - Ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of synthetic method
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Paragraph 0037; 0038-0048, (2019/07/05)
The invention belongs to the field of medicinal chemistry, in particular to medicinal chemistry of the in the field of organic synthesis, more in particular to 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of synthetic method. The method uses acetonitrile with a ester alcohol under the action of the alkali metal salt, to obtain the intermediate compound II, then this compound II and then under the action of the phase transfer catalyst, with the sulfuric acid b b obtained by the target mixture compound I, namely 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture. The invention disclosed 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of the synthetic method has low material cost, relatively mild reaction conditions, the operation is simple, the yield and the like, which is suitable for the industrial production, application of the method.
