1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

Base Information

Chemical Name:1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide
CAS No.:1375183-37-1
Molecular Formula:C₁₃H₁₁FN₆S
Molecular Weight:302.335
Hs Code.:

Synonyms:1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

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Chemical Property of 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

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Technology Process of 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

There total 3 articles about 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1375183-36-0
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carbonitrile

: 1375183-37-1
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

Guidance literature:: 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carbonitrile; With methanol; sodium methylate; at 20 ℃; for 5h;

With ammonium chloride; In methanol; at 20 ℃; for 17h;

With sodium hydrogencarbonate; sodium hydroxide; In methanol; water;

Reference yield:

: 1375183-33-7
ethyl 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxylate

: 1375183-37-1
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia; sodium cyanide / methanol / 24 h / 90 °C / Sealed tube

2.1: trifluoroacetic anhydride; pyridine / 2.08 h / 0 - 20 °C

3.1: sodium methylate; methanol / 5 h / 20 °C

3.2: 17 h / 20 °C

With pyridine; methanol; sodium cyanide; ammonia; sodium methylate; trifluoroacetic anhydride; In methanol;

Reference yield:

: 1375183-34-8
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxamide

: 1375183-37-1
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride; pyridine / 2.08 h / 0 - 20 °C

2.1: sodium methylate; methanol / 5 h / 20 °C

2.2: 17 h / 20 °C

With pyridine; methanol; sodium methylate; trifluoroacetic anhydride;