ASISCHEM C66312

Base Information

• Chemical Name: ASISCHEM C66312
• CAS No.: 928710-55-8
• Molecular Formula: C₁₂H₁₀F₂O₂
• Molecular Weight: 224.207
• Mol file: 928710-55-8.mol

Synonyms:C₁₂H₁₀F₂O₂

Chemical Property of ASISCHEM C66312

Chemical Property:

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

5-(3,5-Difluorophenyl)cyclohexane-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ASISCHEM C66312

There total 2 articles about ASISCHEM C66312 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl malonate (105-53-3) + (E)-4-(3,5-Difluoro-phenyl)-but-3-en-2-one → C12H10F2O2 (928710-55-8)

Guidance literature:

diethyl malonate; (E)-4-(3,5-Difluoro-phenyl)-but-3-en-2-one; With sodium ethanolate; In ethanol; for 12h;

With sodium hydroxide; In ethanol; water; for 12h;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1016/j.bmc.2011.11.039

Reference yield:

3,5-difluorobenzaldehyde (32085-88-4) → C12H10F2O2 (928710-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 12 h / 20 °C

2.1: sodium ethanolate / ethanol / 12 h

2.2: 12 h

With sodium ethanolate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2011.11.039

Reference yield: 81.0%

5-Amino-4-cyano-1-phenylpyrazole (5334-43-0) + C12H10F2O2 (928710-55-8) → 4-amino-7-(3,5-difluorophenyl)-1-phenyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one

Guidance literature:

5-Amino-4-cyano-1-phenylpyrazole; C₁₂H₁₀F₂O₂; In toluene; for 1h; Reflux; Dean-Stark;

With tin(IV) chloride; In toluene; for 6h; Reflux; Dean-Stark;

DOI:10.1007/s10593-017-2041-9

upstream raw materials:

3,5-difluorobenzaldehyde

diethyl malonate

Refernces