6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride

Base Information

• Chemical Name: 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride
• CAS No.: 1469858-00-1
• Molecular Formula: C₂₄H₂₃N₅S*ClH
• Molecular Weight: 450.007

Synonyms:6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride

Chemical Property of 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride

Chemical Property:

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Technology Process of 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride

There total 9 articles about 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene (1469858-71-6) → 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride (1469858-00-1)

Guidance literature:

With hydrogenchloride; In methanol; at 100 ℃; for 4h;

Reference yield:

5,6-dihydro-<6H>-cyclopenta--thiophene-4-one (5650-51-1) → 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride (1469858-00-1)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 8 h / 100 °C

2: hydrazine hydrate; acetic acid / ethanol / 4 h / 100 °C / Inert atmosphere

3: sodium hydride / mineral oil; tetrahydrofuran / 2.5 h / 0 - 80 °C

4: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 8 h / 100 °C

5: N-Bromosuccinimide / 2 h

6: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

7: hydrogenchloride / methanol; water / 4 h / 100 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; palladium diacetate; sodium hydride; sodium carbonate; caesium carbonate; hydrazine hydrate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; toluene; mineral oil;

Reference yield:

6-(4-bromophenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene (1469858-10-3) → 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride (1469858-00-1)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 8 h / 100 °C

2: N-Bromosuccinimide / 2 h

3: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

4: hydrogenchloride / methanol; water / 4 h / 100 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; palladium diacetate; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethanol; water; toluene;

upstream raw materials:

6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

6-(4-bromophenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

methyl 3-chlorobenzoate

6-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

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