6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

Base Information

Chemical Name:6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene
CAS No.:1469858-71-6
Molecular Formula:C₃₀H₃₇N₅OSSi
Molecular Weight:543.808
Hs Code.:

Synonyms:6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

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Chemical Property of 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

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Technology Process of 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

There total 7 articles about 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1469858-69-2
2-bromo-6-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

: 329214-79-1
3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1469858-71-6
6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In ethanol; toluene; at 100 ℃; for 8h;

Reference yield:

: 1469857-12-2
6-(4-bromophenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

: 1469858-71-6
6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 80 °C

2: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 8 h / 100 °C

3: N-Bromosuccinimide / dichloromethane / 2 h

4: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; palladium diacetate; sodium hydride; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene; mineral oil;

Reference yield:

: 1469858-10-3
6-(4-bromophenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

: 1469858-71-6
6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 8 h / 100 °C

2: N-Bromosuccinimide / dichloromethane / 2 h

3: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; palladium diacetate; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dichloromethane; toluene;