<(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate

Base Information

Chemical Name:<(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate
CAS No.:149261-38-1
Molecular Formula:C₂₅H₃₁N₅O₅
Molecular Weight:481.552
Hs Code.:

Synonyms:<(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate

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Technology Process of <(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate

There total 6 articles about <(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 149228-91-1
2-Azidomethyl-N-hydroxymethyl-6,N-dimethylbenzamide

: 149261-38-1
<(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 17h; Ambient temperature;

Reference yield:

: 632-46-2
2,6-dimethylbenzoic acid

: 149261-38-1
<(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1) PCl₅ / 1) 80 deg C, 30 min, 2) 30 min

2: NBS, dibenzoyl peroxide / CCl₄ / 7 h / Heating

3: NaN₃ / ethanol / 40 h / Ambient temperature

4: 57 percent / methanol / 6 h / Ambient temperature

5: 71 percent / K₂CO₃ / acetonitrile; H₂O / 5 h / Ambient temperature

6: 65 percent / diisopropylcarbodiimide, 4-(N,N-dimethylamino)pyridine / dimethylformamide; CH₂Cl₂ / 17 h / Ambient temperature

With dmap; N-Bromosuccinimide; sodium azide; phosphorus pentachloride; potassium carbonate; diisopropyl-carbodiimide; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 17847-75-5
2,6-Dimethylbenzoic acid 4-nitrophenyl ester

: 149261-38-1
<(2-Azidomethyl-6-methylbenzoyl)(methyl)amino>methyl-2-(<(tert-butoxy)carbonyl>amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: NBS, dibenzoyl peroxide / CCl₄ / 7 h / Heating

2: NaN₃ / ethanol / 40 h / Ambient temperature

3: 57 percent / methanol / 6 h / Ambient temperature

4: 71 percent / K₂CO₃ / acetonitrile; H₂O / 5 h / Ambient temperature

5: 65 percent / diisopropylcarbodiimide, 4-(N,N-dimethylamino)pyridine / dimethylformamide; CH₂Cl₂ / 17 h / Ambient temperature

With dmap; N-Bromosuccinimide; sodium azide; potassium carbonate; diisopropyl-carbodiimide; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;